I would. Stafford is injury prone, but he is having a great season. The saints spread the ball around, so none of the WR's get consistent points from week to week. It also depends on your current QB and WR depth.
It does depend on your current QB/WR situations, but personally I'd make this move. Colston is pretty much just as injury prone as Stafford, and he is on absolute fire so far.
Depends on who your current QB is, but Stafford is arguably a top-5 fantasy QB when he's healthy. I'd take that deal.